Signal regulatory protein alpha
WebDec 25, 2013 · Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory … WebApr 10, 2024 · Karyopherin subunit alpha 1 (KPNA1), also known as importin alpha 5 in human, is a cytoplasmic protein belonging to the importin alpha family and is involved in …
Signal regulatory protein alpha
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WebThe anti-CD47 antibody or an antigen-binding fragment thereof is capable of blocking the interaction of CD47 with signal regulatory protein alpha (SIRPalpha). Further envisaged is an anti-CD47 antibody or antigen-binding fragment combined to … Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don't eat me" signal. This interaction … See more The cytoplasmic region of SIRPα is highly conserved between rats, mice and humans. Cytoplasmic region contains a number of tyrosine residues, which likely act as ITIMs. Upon CD47 ligation, SIRPα is phosphorylated and … See more SIRPα recognizes CD47, an anti-phagocytic signal that distinguishes live cells from dying cells. CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or … See more • Oldenborg PA (2013). "CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease". … See more The extracellular domain of SIRP α binds to CD47 and transmits intracellular signals through its cytoplasmic domain. CD47-binding is mediated … See more Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. In one study, they engineered high-affinity variants of SIRP α that antagonized CD47 on cancer cells and caused increase phagocytosis of cancer cells. Another study … See more
WebFeb 21, 2024 · 30 Signal Regulatory Protein Alpha (SIRPα) V1/V1 homozygous patients with 2nd line recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) who had received prior platinum-based therapy within the recurrent/metastatic setting. Drug: … WebSPINDLY (SPY) is an important regulator of plant development, and consists of an N-half tetratricopeptide repeat (TPR) domain containing 10 TPR motifs and a C-half catalytic domain, similar to O-GlcNAc transferase (OGT) of animals. The best characterised role of SPY is a negative regulator of GA signalling, and all known spy alleles have been isolated …
WebCytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain (PDF) Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain Marina Picciotto - Academia.edu WebMay 19, 2024 · Signal regulatory protein alpha (SIRPα) is a type I transmembrane protein with three extracellular Ig-like domains and two cytoplasmic immunoreceptor tyrosine …
WebSignal Regulatory Proteins (SIRPs) comprise a family of several transmembrane glycoproteins (SIRPα, SIRPβ, and SIRPγ) that belong to immunoglobulin superfamily. SIRPγ is also known as CD172g or SIRPβ2 which is primarily expressed on T cells and a subpopulation of B cells. Like CD172a, the ligand of CD172g is CD47.
WebMar 1, 2009 · On macrophages, for example, SIRPα (signal regulatory protein-α) is a checkpoint receptor that binds the ubiquitously expressed protein CD47, 9, 10, 36,56 … graphic card hotspot temperatureWebSep 25, 2009 · Signal-regulatory protein α (SIRPα) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure … graphic card health testWebBy binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRP α ), CD47 can regulate the function of cells in the monocyte/macrophage lineage. In this … graphic card heatsinkWebCC-95251 is a novel, fully human immunoglobulin G1 antibody (Ab) that binds to SIRPα on macrophages to potently block the CD47–SIRPα interaction. Aims. The primary objectives … graphic card helpWebApr 3, 2024 · The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members … graphic card hubWebNov 30, 2024 · Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes with tumor-specific antibodies and T-cell checkpoint inhibitors by promoting myeloid-mediated antitumor functions leading to the … chip\u0027s niWebJan 16, 2004 · Signal regulatory protein α was cloned from U373MG as described in “Materials and Methods” using PCR. Sequences corresponding to the three … chip\u0027s nice