Klf4 and mitophagy

Author: chve

August undefined, 2024

WebApr 25, 2024 · Treatment of smooth muscle cells with porcine pancreatic elastase or interleukin (IL)-1 β activated autophagy-related genes in vitro while treatment with a siRNA to Kruppel-like transcription factor 4 ( Klf4 ), Kruppel-like transcription factor 2 ( Klf2) or Zinc-finger protein 148 ( Zfp148) separately inhibited activation of autophagy genes. WebKLF4 in cardiac cells inhibited promoter transactivation of mitochondrial DNA. The accumulation of fragmented mitochondria in KLF4-deficient cardiac cells warranted further investigation. An outstanding question that remained was whether KLF4 loss-of-function handicaps the process of autophagy. Indeed, KLF4 regulates genes involved in

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion …

WebDec 5, 2024 · In this study, we sought to identify a mechanistic connection between KLF4 and mitophagy. Using flow cytometry, we found that Klf4-null MEFs have … WebHere, using human glioblastoma cells, we investigated KLF4’s effects on cancer cell metabolism. We found that forced KLF4 expression promotes mitochondrial fusion and … should i buy blk stock

Transcriptional regulation of autophagy and its implications in …

WebMitophagy plays an important role in maintaining mitochondria ... Sox2, Klf4 and c-Myc, is sufficient to reverse-differentiate fibroblasts into pluripotent stem cells (22). Interestingly, recent ... WebIdiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease with high mortality and unclear etiology. Previous evidence supports that the origin of this disease is associated with epigenetic alterations, age, and environmental factors. IPF initiates with chronic epithelial lung injuries, followed by basal membrane destruction, which promotes the … WebAmong miR-143/145 target genes, the transcription factor KLF4 is a positive regulator of glutathione transferases and autophagy/mitophagy genes [96]. These lines of evidence … should i buy biomutant

Key protein drives

WebDec 10, 2024 · In the lung, KLF4 has been implicated in the normal perinatal accumulation of myofibroblasts as Klf4(−/−) neonates lack alveolar myofibroblasts, and expression of … WebMitophagy serves as a key cellular quality control mechanism involving sequestration of damaged mitochondria within autophagosomes and their subsequent degradation in lysosomes. However, it remains largely unknown whether mitophagy is involved in the regulation of energy metabolism in neurons, and if so, whether metabolic deficiency in AD … should i buy black or brown bootsWebApr 7, 2024 · Krüppel-like factor 4 (KLF4), a context-dependent transcription factor that can act as both a tumor suppressor and an oncogene, is involved in many molecular pathways that respond to low glucose and increased reactive oxygen species (ROS), raising the question of its role in metabolic stress as a result of increased proliferation of tumor cells. should i buy bitcoin gold

"WebMar 1, 2024 · Open access. •. Sirt6 can promote autophagy in endothelial cells treated with AGE. •. Sirt6 exerts this autophagy-promotion function by KLF4 in endothelial cells treated with AGE. •. Sirt6 directly regulates KLF4. •. Sirt6 induces more autophagosomes formation in endothelium of STZ-induced diabetic mice. " - Klf4 and mitophagy

Klf4 and mitophagy

Emerging role of mitophagy in human diseases and physiology

WebMay 9, 2024 · Mitophagy is a process of selectively degrading damaged mitochondria under mitochondrial toxicity conditions, which plays an essential role in mitochondrial quality control. The abnormal... WebMitophagy plays an important role in maintaining mitochondria ... Klf4 and c-Myc, is sufficient to reverse-differentiate fibroblasts into pluripotent stem cells (22). Interestingly, recent studies have reported that the transi-tion of mitochondrial restructuring and energy metabolism are

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WebTNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. WebAug 4, 2015 · The initial hint that KLF4 regulates mitochondrial biology came from genome-wide studies that revealed a strong signature for KLF4's control of mitochondrial genes. Next, Liao and his...

WebNov 24, 2014 · KLF4 deficiency in mouse bone marrow drastically reduced lung metastasis that was accompanied by decreased recruitment of CCR2 + MDSCs in the lung. (a) Six … WebOct 13, 2024 · Finally, studies from our laboratory have reported that KLF4 regulation of mitophagy in cardiomyocytes is critical for mitochondrial homeostasis and the cardiac response to stress occurring...

WebApr 12, 2024 · Download Citation Transcriptional regulation of autophagy and its implications in human disease Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell ... WebMay 26, 2024 · Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth muscle cells. Mitophagy is an autophagic response that specifically targets damaged, and hence potentially cytotoxic, mitochondria. As these organelles occupy a …

WebJan 1, 2024 · In this study, we sought to identify a mechanistic connection between KLF4 and mitophagy. Using flow cytometry, we found that Klf4 -null MEFs have diminished …

WebJan 9, 2024 · Conclusion: ATPIF1 maintains the normal structure of mitochondria, inhibiting the activation of mitophagy and other signaling pathway in endothelial cells. Loss of … satba clothWebFeb 19, 2024 · It is well-known that atherogenesis is a complex multi-component process that includes lipid metabolism disorders, inflammation, oxidative stress, autophagy disorders and mitochondrial dysfunction. Autophagy is a cellular control mechanism that is critical to maintaining health and survival. should i buy blok stockWebby selective autophagy – or mitophagy – which degrades defective mitochondria via the lysosomal machinery. The ... KLF4, and c-MYC) are suffi-cient to reprogram differentiated somatic cells into ESC-like cells, designated as iPSCs, shifted the paradigm of unidirection-al cellular development and cell fate. The idea of reprogram- satay thai box kelownaWebKLF4-expressing cells portrayed evidence of extensive mitochondrial fusion that may explain the delayed cell death. Mechanistically, KLF4 did not directly regulate the three … should i buy blackberryWebDec 1, 2024 · Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after … should i buy bitcoin on cash appWebApr 7, 2024 · Recently, KLF4 has been found to regulate mitophagy and mitochondria dynamics, indicating a relationship between the transcription factor and cellular … should i buy blinds or shadesWebJan 1, 2024 · Klf4 deficiency aggravates myocardial injury by increasing cardiomyocyte death, heart infarction size, superoxide generation and lipid peroxidation. Impaired mitochondrial respiratory capacity and increased mitochondrial apoptosis are the possible mechanisms involved in this process. should i buy bonds in 2023